The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.
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Minisatellites have been associated with chromosome fragile sites and are proximal to a number of recurrent translocation breakpoints. This article may be confusing or unclear to readers. In miinisatellite models, it is the presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations.
Hypervariable ‘minisatellite’ regions in human DNA
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Wikipedia articles needing clarification from July All Dnq articles needing clarification Articles needing expert attention with no reason or talk parameter Articles needing expert attention from July All articles needing expert attention Genetics articles needing expert attention Articles with multiple maintenance issues All articles with unsourced statements Articles with unsourced statements from May Citing articles via Web of Science When shorter 10—bp tandem repeats were later identified, they came to be known as minisatellites.
In contrast, complex inter-allelic conversion-like events occur in the germline. Repeat turnover therefore appears to be controlled by recombinational activity in DNA that flanks the repeat array and results in a minisatellife of mutation.
Close mobile search navigation Article navigation. If you originally registered with a username please use that to sign in. Finally, with the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined.
Somatic instability detected in blood DNA shows simple and rare intra-allelic events two to three orders of minisatelite lower than in sperm.
Hypervariable ‘minisatellite’ regions in human DNA.
You could not be signed in. Please help improve it or discuss these issues on the talk page. Sequences flanking hypervariaboe repeat arrays of human minlsatellites: You have entered an invalid code.
It has been proposed that minisatellite sequences encourage chromosomes to swap DNA. You do not currently have access to this article. Studies have revealed distinct mutation processes operating in somatic and germline cells.
Minisatellite – Wikipedia
Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: Minisatellites are small sequences of DNA that do not encode proteins but appear throughout the genome hundreds of times, with many repeated copies lying next to each other. This page was last edited on 2 Novemberat Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage.
These findings have suggested that minisatellites most probably evolved as bystanders of localized meiotic recombination hotspots in the human genome. Your comment will be reviewed and published at the journal’s discretion.
For the size class of orbiting spacecraft, see miniaturized satellite. A minisatellite is a tract of repetitive DNA in which certain DNA motifs ranging in length from 10—60 base pairs are typically repeated times. Please add a reason or a talk parameter to this template to explain the issue with the article.
Such an event would ultimately lead to the extinction of a hypermutable minisatellite by meiotic drive. Emery’s Elements of Medical Genetics, 12th.
Abstract We present DNA sequences flanking cloned hypervariable human minisatellites. There might be a discussion about this on the talk page.