Thus, latent infection of resting CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective anti-retroviral therapy. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of Diana Finzi;, Joel Blankson;, Janet D. Siliciano;, Joseph B. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, Smith K.
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Viewed in this context, several research goals assume lifelomg importance. The source of this rebound virus has not been determined. Nature Medicine5 5 Toward an HIV Cure.
Correlation of virus load in plasma and lymph node tissue in human immunodeficiency virus infection. Citations Publications citing this paper.
JCI – Latency and viral persistence in HIV-1 infection
CrandallDavid Posada Infection, genetics and evolution: Combined Modality Therapy Antiretroviral therapy. A rebound is still expected due to activation of cells in the latent reservoir. Finally, novel approaches are needed to eliminate latently infected cells, which clearly represent a very serious barrier to HIV-1 eradication. In patients who respond well to HAART, viremia decreases to below the limits of detection, disease progression stops, and reconstitution of the immune system begins.
This paper has highly influenced 26 other papers. Second, it is important to understand the nature and source of the lifelonf virus production that is seen in most patients on HAART. Flexner The New England journal of medicine First, it is critical to determine whether additional viral reservoirs exist. Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might mmechanism the infection.
Of course, continued low-level virus production could reflect release of virus from some stable reservoir without the generation of newly infected cells. For the first time since the beginning of the epidemic, the possibility of curing HIV-1 infection has been seriously considered 1.
Although these cells do not continue to produce virus while in a resting state, they can function as a latent reservoir, capable of reinitiating virus production upon reactivation. If the latent reservoir consists of only 1 x 10 5 cells, eradication could take as long as 60 years.
CD4+ T Cell Mechanism Allows HIV-1 Persistence
Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy. Identification of a reservoir for HIV – 1 in patients on highly active antiretroviral therapy. Find articles by Siliciano, J. An important study by David Ho and colleagues in this issue of JCI 7 suggests that the latent reservoir may be the source of this rebound virus.
The rebound virus may therefore be derived from a small number of cells in the reservoir that happened to be activated when HAART was stopped. Fauci Proceedings of the National Academy of Sciences….
Nature MedicineVol. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable.
CD4+ T Cell Mechanism Allows HIV-1 Persistence | The Scientist Magazine®
Highly active antiretroviral therapy. N2 – Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection.
Showing of extracted citations. First published October 1, – More info. Commentary Free access Abstract Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection.
The simplest interpretation of both studies is that, in many cases, viruses in the latent reservoir resemble the rebound virus; where differences exist, they may reflect sampling problems, the presence of additional long-term reservoirs for HIV-1, or the failure of HAART to completely halt viral replication.
Both of these studies provide insights into mechanisms of viral persistence. There are caveats, however, related to sampling and founder effects.
Sampling is less of a concern in the study of Zhang et al. The second, slower phase of decay is still fast enough to allow eradication of residual infected cells in 2—3 years. Version 1 October 1, Skip to search form Skip to main content. Sign up for email alerts. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable.
However, env sequences amplified from initial rebound viruses from the other three patients were different in length from latent reservoir sequences. In these patients, the latent reservoir persists with an extremely long half-life 44 months.
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