Posted on April 21, 2019


Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive genetic disorder caused by an abnormality in the CYP27A1 gene, resulting in a deficiency. Disease definition. Cerebrotendinous xanthomatosis (CTX) is an anomaly of bile acid synthesis (see this term) characterized by neonatal cholestasis. Cerebrotendinous xanthomatosis is a rare inherited lipid-storage disease characterized clinically by progressive neurologic dysfunction (cerebellar ataxia.

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Cerebrotendinous Xanthomatosis (CTX)

Together we are strong. Infantile Jansky—Bielschowsky disease Batten disease. Long-term therapy with chenodeoxycholic acid has been effective in treating affected individuals. Mean age of diagnosis is CTX should be suspected in patients with some combination of infantile onset diarrhea, juvenile onset bilateral cataracts, adolescent to young adult-onset tendon xanthoma, and adult-onset progressive neurologic dysfunction.

The standard treatment is chenodeoxycholic acid CDCA replacement therapy. Long-term bone density evaluation in cerebrotendinous xanthomatosis: The progression of disease was arrested in all xanthomatpsis patients, but no dramatic reversal of clinical manifestations was seen. Psychiatric abnormalities including behavioral changes, hallucinations, agitation, aggression, depression, and suicidal tendencies can also occur, although specific expression varies greatly.

Both patients had high plasma levels of cholestanol. Recent estimates for the incidence of CTX range from 1: SLOS is an autosomal recessive disorder associated with mutations in DHCR7 gene that reduces or eliminates the activity of 7-dehydrocholesterol reductase.


Rare Disease Database

For example, cataract surgery may be necessary before 50 years of age. This gene is responsible for producing an enzyme called sterol hydroxylase.

The brother had slowly progressive ataxia in later years. Genes provide instructions for creating proteins that play a critical role in many functions of the body. This page has been accessed 11, times. All studies receiving U. Serum cholesterol levels are also followed. Premature retinal senescence was also observed. Views Read Edit View history.

Cognitive impairment can be mild to severe but becomes progressively worse without treatment. Under normal conditions, sterol hydroxylase works in a pathway to break down cholesterol into bile acids necessary for the body to digest fats.

Cerebrotendineous xanthomatosis – Wikipedia

Residents and Fellows contest rules International Ophthalmologists contest rules. The prevalence of CTX in the US population is estimated to be as high as 3 to 5 per , predicting a minimum number of 8, affected individuals. A number sign is used with this entry because cerebrotendinous xanthomatosis is caused by homozygous or compound heterozygous mutation in the CYP27A1 genewhich encodes sterol hydroxylase, on chromosome 2q Neuropsychiatric symptoms such as behavioral changes, hallucinations, agitation, aggression, depression, and suicidal tendencies may be prominent.


In untreated patients, life cerebrotendinouz is 50 to 60 years. Mutations in the bile acid biosynthetic enzyme sterol hydroxylase underlie cerebrotendinous xanthomatosis. Cerebrotendinous xanthomatosis van Bogaert-Scherer-Epstein disease: As the disorder progresses affected individuals can become incapacitated with motor dysfunction, and affected individuals may die prematurely due to advancing neurological deterioration. Diagnosis was best based on determination of urinary bile alcohols, in particular 5-beta-cholestanealpha,7-alpha,alpha,23,pentol, by means of capillary gas chromatography.

Plasma cholesterol concentrations cerebrotedinous low normal in CTX patients. Features of cholestasis include yellowing of the skin, mucous membranes and whites of the eyes jaundicefailure to thrive, and growth deficiency. They are an important component of bile and help the intestine to absorb fats.

Cerebrotendinous xanthomatosis as a multisystem disease mimicking premature aging. Summary and related texts. Mutations in the CYP27A1 gene prevent critical steps in the bile acid synthesis that leads to bile acid deficiency, which results in a buildup of cholestanol throughout the body that causes distinctive clinical manifestations.